Ebola vaccine seems safe in 1st-stage test

Associated Press

WASHINGTON

An experimental Ebola vaccine appears safe and triggered signs of immune protection in the first 20 volunteers to test it, U.S. researchers reported Wednesday.

The vaccine is designed to spur the immune system’s production of anti-Ebola antibodies, and people developed them within four weeks of getting the shots at the National Institutes of Health. Half of the test group received a higher-dose shot, and those people produced more antibodies, said the study published in the New England Journal of Medicine.

Some people also developed a different set of virus- fighting immune cells, named T cells, the study found. That may be important in fending off Ebola, as prior research found that monkeys protected by the vaccine also had that combination response.

Stimulating both types of immune response is “a promising factor,” said Dr. Anthony Fauci, director of NIH’s National Institute of Allergy and Infectious Diseases, whose employees led the work.

The researchers reported no serious side effects. But two people who received the higher-dose vaccine briefly spiked fevers, one above 103 degrees, which disappeared within a day.