A touchy treatment

June 23, 2011 at 12:00a.m.

Psoriasis drug promises big results, but side effects raise concerns

Detroit Free Press

DETROIT

Take a shot and make it go away.

That’s quite tempting if you have a disease such as psoriasis, an often itchy, painful skin problem that can take months to get rid of.

But doctors at leading centers are raising concerns that new injectable medicines — a class of drugs called biologics — for the skin disease can bring their own problems, including infections that trigger more skin outbreaks, tuberculosis and rare cases of lymphoma, a type of cancer.

“The hoopla is that with these new drugs, a person can get a shot that takes care of their psoriasis for three months; that’s a good thing,” said Dr. Thomas Anderson, medical director of the University of Michigan Day Treatment Center.

“But as time goes on, these drugs may not be as effective in some patients,” Anderson said. “If you get an infection while you are on one of those drugs, your body may not be as capable of getting rid of it.”

For that reason, many patients might be best off trying conventional treatments first: moisturizing creams, lasers or light treatments known as phototherapy.

After using the biologic drugs, Kathy Bommarito, 42, of Clawson, Mich., developed strep throat and a horrible case of psoriasis.

“It’s very painful, like a very bad sunburn,” said Bommarito of the disease. Her dad also had psoriasis, which can be hereditary.

Bommarito’s psoriasis abated after a week of light and moisturizing treatments at the University of Michigan, but returned 10 days later. She’s back to taking the biologic drug, Stelara, and light treatments three times a week.

Brand names for other biologics include Amevive, Enbrel, Remicade, Humira and Raptiva. The drugs, which have come on the market in the past decade, affect the immune system but may cause infections.

Safety warnings listed on the labels for the drugs mention the chance of serious infections, TB and cancer, and recommend that people tell doctors before filling a prescription if they have diabetes, are scheduled for major surgery, are pregnant, have heart failure, cancer or nervous- system disorders.

Doctors at the University of Michigan and Detroit’s Henry Ford Hospital tell patients that biologics aren’t often the best first choice because of the problems associated with them.

“We almost always try other things first,” said Dr. Iltefat Hamzavi, a Canton, Mich., dermatologist and Henry Ford Health System physician. Hamzavi limits the drugs to patients with psoriasis over 10 percent or more of their body, or people with arthritic psoriasis, a painful joint problem. Psoriatic arthritis usually appears between the ages of 30 and 50 and is believed to be triggered by genes, the immune system and environmental factors, according to the National Psoriasis Foundation.

Cost is another issue with the biologics. The injectables run $22,000 to nearly $60,000 a year, compared with $10,000 to $20,000 for moisturizing and light therapy, depending on the duration of the therapy.

The University of Michigan and Ford both offer moisturizing treatments known as modified Goeckerman therapy.

The moisturizers, made from a coal - tar substance. Some patients are completely clear of their outbreaks after treatment and have gone as long as 10 years without another episode, University of Michigan doctors say.

Tar from both coal and wood are used to create creams that help slow overactive growth of skin cells and reduce the inflammation, itching and scaling of psoriasis.

The creams also make the skin more sensitive to light treatments and make it possible to reduce the number of phototherapy sessions needed.

Jeanine Witten, nurse supervisor of the University’ of Michigan’s outpatient dermatology program, said the moisturizing creams must be applied carefully in a downward motion to avoid causing pimples.

Laser treatments entail 13 to 20 treatments that last five to 10 minutes each, Hamzavi said. Three out of four patients get at least 75 percent clearance of their psoriasis with laser treatments, which can last four to six months or longer, he said.