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CLEVELAND (0-4) at BUFFALO (1-3)

Game time: 1 p.m.

TV/radio: (27) (19); (WKBN-AM 570) (WNCD-FM 93.3)

Opening line: Bills by 6. Record vs. spread: Cleveland 1-3; Buffalo 2-2

Series record: Browns lead 9-5. Last meeting: Browns beat Bills 29-27, Nov. 17, 2008

Notebook: Browns and Bills have among NFL’s worst records since 2000, not including Houston, which joined league in ’02. Cleveland is 52-96, to rank 30th ahead of only Detroit, while Buffalo is tied with Cincinnati for 26th at 61-87. ... Browns came back to NFL in 1999 and went 2-14. ... Browns have lost 10 straight dating to their win against Buffalo. ... By trading WR Braylon Edwards to Jets, Browns have dealt their top two receiving threats from last season after tight end Kellen Winslow was sent to Tampa Bay in February. ... Rookie WR Mohamed Massaquoi last week had 148 yards receiving, most by Browns rookie since Derrick Alexander had 171 yards in 1994. ... QB Derek Anderson will make second start this year after generating 395 yards offense last weekend, most by Cleveland since 34-30 loss to Denver last Nov. 9. ...

PITTSBURGH (2-2) at DETROIT (1-3)

Game time: 1 p.m.

TV/Radio: (2); (WNIO-AM 1390)

Opening line: Steelers by 12. Record vs. spread: Steelers 1-3; Lions 1-3

Series record: Tied 14-14-1. Last meeting: Steelers beat Lions 35-21, Jan. 1, 2006

Notebook: Steelers have won 10 of last 12 games against Lions, falling in regular-season matchup in OT after controversial coin flip in 1998 Thanksgiving game. ... at Detroit’s Ford Field, Pittsburgh beat Seattle to win Super Bowl in 2006. ... Ben Roethlisberger made pro debut in 2004 exhibition game at Ford Field, which is 45-minute drive from the Big House, where QB played his first college game in 2001 for Miami (Ohio) against Michigan. ... Roethlisberger is 15-5 against NFC. ... RB Rashard Mendenhall ran for 165 yards on 29 carries, filling in for injured Willie Parker. ... Since 2008, LB James Harrison is tied with Joey Porter for second in NFL with 19 sacks — one fewer than DeMarcus Ware.

OAKLAND (1-3) at N.Y. GIANTS (4-0)

Game time: 1 p.m.

Opening line: Giants by 15. Record vs. spread: Oakland 2-2; New York 3-1

Series record: Raiders lead 7-3. Last meeting: Giants beat Raiders 30-21, Dec. 31, 2005

MINNESOTA (4-0) at ST. LOUIS (0-4)

Game time: 1 p.m.

Opening line: Vikings by 91‚Ñ2. Record vs. spread: Minnesota 3-1; St. Louis 1-3

Series record: Vikings lead 16-14-2. Last meeting: Rams beat Vikings 41-21, Dec. 23, 2006

WASHINGTON (2-2) at CAROLINA (0-3)

Game time: 1 p.m.

Opening line: Panthers by 51‚Ñ2. Record vs. spread: Washington 1-3; Carolina 0-3.

Series record: Washington leads 7-1. Last meeting: Redskins beat Panthers 17-13, Nov. 26, 2006

TAMPA BAY (0-4) at PHILADELPHIA (2-1)

Game time: 1 p.m.

Opening line: Eagles by 14. Record vs. spread: Tampa Bay 1-3; Philadelphia 2-1

Series record: Tied 5-5. Last meeting: Buccaneers beat Eagles 23-21, Oct. 22, 2006

DALLAS (2-2) at KANSAS CITY (0-4)

Game time: 1 p.m.

Opening line: Cowboys by 9. Record vs. spread: Dallas 2-2; Kansas City 0-4

Series record: Cowboys lead 5-3. Last meeting: Cowboys beat Chiefs 31-28, Dec. 11, 2005

CINCINNATI (3-1) at BALTIMORE (3-1)

Game time: 1 p.m.

Opening line: Ravens by 81‚Ñ2. Record vs. spread: Bengals 2-2-0; Ravens 3-1-0

Series record: Ravens lead 15-11. Last meeting: Ravens beat Bengals 34-3, Nov. 30, 2008

ATLANTA (2-1) at SAN FRANCISCO (3-1)

Game time: 4:05 p.m.

TV: (17/62)

Opening line: Pick-em. Record vs. spread: San Francisco 4-0; Atlanta 2-1

Series record: 49ers lead 44-28-1. Last meeting: Falcons beat 49ers 20-16, Nov. 4, 2007

HOUSTON (2-2) at ARIZONA (1-2)

Game time: 4:15 p.m.

Opening line: Cardinals by 5. Record vs. spread: Houston 2-2; Arizona 1-2

Series record: Texans lead 1-0. Last meeting: Texans beat Cardinals 30-19, Dec. 18, 2005

JACKSONVILLE (2-2) at SEATTLE (1-3)

Game time: 4:15 p.m.

Opening line: OFF. Record vs. spread: Jacksonville 3-1; Seattle 1-3

Series record: Seahawks lead 3-2. Last meeting: Jaguars beat Seahawks 26-14, Sept. 11, 2005

NEW ENGLAND (3-1) at DENVER (4-0)

Game time: 4:15 p.m.

Opening line: Patriots by 31‚Ñ2. Record vs. spread: New England 1-3; Denver 4-0

Series record: Broncos lead 24-16. Last meeting: Patriots beat Broncos 41-7, Oct. 20, 2008

INDIANAPOLIS (4-0) at TENNESSEE (0-4)

Game time: 8:20 p.m.

TV: (21) (3) (11)

Opening line: Colts by 3. Record vs. spread: Houston 3-1; Tennessee 1-3

Series record: Colts lead 16-12. Last meeting: Colts beat Titans 23-0, Dec. 28, 2008.

Associated Press