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SAN DIEGO (8-3) at CLEVELAND (1-10)

Game time: 4 p.m.

TV/Radio: (27) (19) (WKBN-AM 570) (WNCD-FM 93.3)

Opening line: Chargers by 111‚Ñ2. Record vs. spread: San Diego 6-5; Cleveland 5-6

Series record: Chargers lead 13-7-1. Last meeting: Chargers beat Browns 32-25, Nov. 5, 2006

Notebook: With six straight losses, banged-up Browns are off to worst start in franchise history in coach Eric Mangini’s first season. ... Cleveland lost two of its top players this week as Pro Bowl nose tackle Shaun Rogers (leg) and RB Jamal Lewis (concussion) were placed on injured reserve. ... Lewis announced this would be his last season and he retires as 21st ranked rusher in league history with 10,607 yards. ... Browns will play four of last five at home.

OAKLAND (3-8) at PITTSBURGH (6-5)

Game time: 1 p.m.

Radio: (2) (WNIO-AM 1390)

Opening line: Steelers by 131‚Ñ2. Record vs. spread: Oakland 5-6; Pittsburgh 4-7

Series record: Raiders lead 12-11. Last meeting: Raiders beat Steelers 20-13, Oct. 29, 2006

Notebook: Steelers average 138 yards per game more than Raiders (372.4-234.4) and allow 88.5 yards per game fewer (376.9-288.4). ... Steelers QB Ben Roethlisberger threw four interceptions, two for touchdowns, during 2006 loss in Oakland — one week after sustaining concussion. He sat out Steelers’ loss Sunday due to post-concussion headaches. ... Roethlisberger (2,807 yards) needs 193 yards for fourth consecutive 3,000-yard passing season. ... Steelers are playing first of two games in five days; they play at Browns (1-10) on Thursday. Steelers’ remaining five opponents have .400 winning percentage, tied with Baltimore for lowest among 12 AFC teams within one game of .500 or better. ... Steelers failed to allow return touchdown last week for first time in nine games. ... Even if Steelers finish 5-0, Bengals (8-3) would have to go 2-3 for Pittsburgh to repeat as AFC North champions.

TENNESSEE (5-6) at INDIANAPOLIS (11-0)

Game time: 1 p.m.

Opening line: Colts by 71‚Ñ2. Record vs. spread: Tennessee 5-6; Indianapolis 7-4

Series record: Colts lead 17-12. Last meeting:Colts beat Titans 31-9, Oct. 11, 2009

DETROIT (2-9) at CINCINNATI (8-3)

Game time: 1 p.m.

TV: (17/62) (8) (53)

Opening line: Bengals by 13. Record vs. spread: Detroit 2-8-1; Cincinnati 6-5

Series record: Bengals lead 6-3. Last meeting:Bengals beat Lions 41-17, Dec. 18, 2005

TAMPA BAY (1-10) at CAROLINA (4-7)

Game time:1 p.m.

Opening line: Panthers by 6. Record vs. spread: Tampa Bay 4-7; Carolina 4-7

Series record: Carolina leads 11-7. Last meeting: Panthers beat Buccaneers 28-21, Oct. 18, 2009

NEW ENGLAND (7-4) at MIAMI (5-6)

Game time: 1 p.m.

Opening line: Patriots by 41‚Ñ2. Record vs. spread: Patriots 6-5; Dolphins 5-6

Series record: Dolphins lead 49-39. Last meeting:Patriots beat Dolphins 27-17, Nov. 8, 2009

NEW ORLEANS (11-0) at WASHINGTON (3-8)

Game time: 1 p.m.

Opening line: Saints by 91‚Ñ2. Record vs. spread: New Orleans 8-3; Washington 5-6

Series record: Redskins lead 15-7. Last meeting: Redskins beat Saints 29-24, Sept. 14, 2008

ST. LOUIS (1-10) at CHICAGO (4-7)

Game time: 1 p.m.

Opening line: Bears by 9. Record vs. spread: St. Louis 5-6; Chicago 4-7

Series record: Bears lead 49-34-3. Last meeting:Bears beat Rams 27-3, Nov. 23, 2008.

HOUSTON (5-6) at JACKSONVILLE (6-5)

Game time: 1 p.m.

Opening line: Pick-em. Record vs. spread: Houston 5-5-1; Jacksonville 4-7

Series record: Texans lead 8-7. Last meeting: Jaguars beat Texans 31-24, Sept. 29, 2009

DENVER (7-4) at KANSAS CITY (3-8)

Game time: 1 p.m.

Opening line: Broncos by 4. Record vs. spread: Denver 7-4; Kansas City 5-6

Series record: Chiefs lead 53-45. Last meeting: Broncos beat Chiefs 24-17, Dec. 7, 2008

PHILADELPHIA (7-4) at ATLANTA (6-5)

Game time: 1 p.m.

Opening line: Eagles by 3. Record vs. spread: Philadelphia 6-5; Atlanta 7-4

Series record:Eagles lead 13-10-1. Last meeting:Eagles beat Falcons 27-14, Oct. 26, 2008

SAN FRANCISCO (5-6) at SEATTLE (4-7)

Game time: 4:15 p.m.

Opening line: 49ers by 1. Record vs. spread: San Francisco 7-2-2; Seattle 4-7

Series record: Seahawks lead 11-10. Last meeting:49ers beat Seahawks 23-10, Sept. 20, 2009

DALLAS (8-3) at NEW YORK GIANTS (6-5)

Game time: 4:15 p.m.

TV: (17/62) (8) (53)

Opening line: Pick-em. Record vs. spread: Dallas 6-5; New York 4-7

Series record: Cowboys lead 55-38-2. Last meeting: Giants beat Cowboys 33-31, Sept. 20, 2009

MINNESOTA (10-1) at ARIZONA (7-4)

Game time: 8:20 p.m.

TV: (17/62) (8) (53)

Opening line: Vikings by 3. Record vs. spread: Minnesota 7-3-1; Arizona 7-4

Series record: Vikings lead 12-9. Last meeting:Vikings beat Cardinals 35-14, Dec. 14, 2008

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