The Frist problem

Los Angeles Times: The best thing a Senate majority leader with presidential aspirations can do is quit. That was Bob Dole's strategy in 1996, when he resigned to run against President Clinton. And it may be part of Bill Frist's decision not to seek re-election in 2006. If so, Frist could hardly make a smarter move.
Of course, abandoning the Senate didn't exactly help Dole in the presidential election, but his campaign was beyond rescue anyway. Dole quit in part because his evident mastery of its rules left the impression that he cared more about recondite parliamentary tactics than he did about the presidency. Frist, who many speculate plans a bid in 2008, has the opposite problem. The longer he tries to run the Senate, the more he looks like a bungler whose only principle is personal advancement.
It has been a particularly bad (period) for Frist. It started when he was outmaneuvered by Senate moderates in his effort to ram through the "nuclear option" and ban judicial filibusters. As the Times has noted, Frist was right to try to get rid of the filibuster. But the defection of seven members of his own party, who joined with seven Democrats to reach a compromise on judicial nominations and leave the filibuster intact, didn't reflect well on his leadership skills.
Stem-cell research
That battle lost, Frist moved on to another defeat, on a bill that would ease restrictions on federal funding for embryonic stem-cell research. The bill passed in the House (last) Tuesday and seems to have a veto-proof majority in the Senate. But Frist is not part of it; he seems to have put his medical knowledge into something like a cryogenic chamber as he ponders whether he's presidential material. And then on Thursday, Frist stood by as Democrats forced a delay in the confirmation of John Bolton, the president's combative nominee for U.N. ambassador.
Frist may be bringing trouble on himself by trying to satisfy the exorbitant demands of his party's far-right wing.